The Slt2-MAPK pathway is involved in the mechanism by which target of rapamycin regulates cell wall components in Ganoderma lucidum.
Identifieur interne : 000201 ( Main/Exploration ); précédent : 000200; suivant : 000202The Slt2-MAPK pathway is involved in the mechanism by which target of rapamycin regulates cell wall components in Ganoderma lucidum.
Auteurs : Dong-Dong Chen [République populaire de Chine] ; Liang Shi [République populaire de Chine] ; Si-Ning Yue [République populaire de Chine] ; Tian-Jun Zhang [République populaire de Chine] ; Sheng-Li Wang [République populaire de Chine] ; Yong-Nan Liu [République populaire de Chine] ; Ang Ren [République populaire de Chine] ; Jing Zhu [République populaire de Chine] ; Han-Shou Yu [République populaire de Chine] ; Ming-Wen Zhao [République populaire de Chine]Source :
- Fungal genetics and biology : FG & B [ 1096-0937 ] ; 2019.
Descripteurs français
- KwdFr :
- Chitine (composition chimique), Chitine (génétique), Interférence par ARN (MeSH), Mitogen-Activated Protein Kinases (composition chimique), Mitogen-Activated Protein Kinases (génétique), Paroi cellulaire (génétique), Paroi cellulaire (métabolisme), Phosphorylation (MeSH), Protéines de Saccharomyces cerevisiae (composition chimique), Protéines de Saccharomyces cerevisiae (génétique), Reishi (génétique), Reishi (métabolisme), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Sirolimus (métabolisme), Système de signalisation des MAP kinases (génétique), Sérine-thréonine kinases TOR (génétique), Sérine-thréonine kinases TOR (métabolisme), bêta-Glucanes (composition chimique).
- MESH :
- composition chimique : Chitine, Mitogen-Activated Protein Kinases, Protéines de Saccharomyces cerevisiae, bêta-Glucanes.
- génétique : Chitine, Mitogen-Activated Protein Kinases, Paroi cellulaire, Protéines de Saccharomyces cerevisiae, Reishi, Saccharomyces cerevisiae, Système de signalisation des MAP kinases, Sérine-thréonine kinases TOR.
- métabolisme : Paroi cellulaire, Reishi, Saccharomyces cerevisiae, Sirolimus, Sérine-thréonine kinases TOR.
- Interférence par ARN, Phosphorylation.
English descriptors
- KwdEn :
- Cell Wall (genetics), Cell Wall (metabolism), Chitin (chemistry), Chitin (genetics), MAP Kinase Signaling System (genetics), Mitogen-Activated Protein Kinases (chemistry), Mitogen-Activated Protein Kinases (genetics), Phosphorylation (MeSH), RNA Interference (MeSH), Reishi (genetics), Reishi (metabolism), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (chemistry), Saccharomyces cerevisiae Proteins (genetics), Sirolimus (metabolism), TOR Serine-Threonine Kinases (genetics), TOR Serine-Threonine Kinases (metabolism), beta-Glucans (chemistry).
- MESH :
- chemical , chemistry : Chitin, Mitogen-Activated Protein Kinases, Saccharomyces cerevisiae Proteins, beta-Glucans.
- genetics : Cell Wall, Chitin, MAP Kinase Signaling System, Mitogen-Activated Protein Kinases, Reishi, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, TOR Serine-Threonine Kinases.
- metabolism : Cell Wall, Reishi, Saccharomyces cerevisiae, Sirolimus, TOR Serine-Threonine Kinases.
- Phosphorylation, RNA Interference.
Abstract
The fungal cell wall is very important for cell growth and survival during stress, and the target of rapamycin (TOR) pathway plays a major role in regulating cell growth in response to environmental cues. Ganoderma lucidum is an important edible and medicinal fungus, and the function of TOR in this organism remains unclear. As shown in the present study, the TOR pathway regulates cell wall integrity (CWI) in G. lucidum. Inhibition of TOR signaling by RNA interference (RNAi) or rapamycin treatment reduced the growth of G. lucidum mycelia, increased contents of the cell wall components chitin and β-1,3-glucan, and increased cell wall thickness. Furthermore, inhibition of TOR signaling enhanced the relative level of phosphorylated Slt2, a member of the MAPK cascade involved in CWI signaling. Moreover, when treated with rapamycin, significantly lower chitin and β-1,3-glucan contents were observed in Slt2-silenced strains than in WT strains, indicating that TOR regulates the synthesis of these cell wall components through the Slt2-MAPK pathway. These results indicate a potential relationship between TOR signaling and CWI signaling. Additionally, participation of Slt2-MAPK in TOR-mediated regulation of cell wall component production has not previously been reported in a microorganism.
DOI: 10.1016/j.fgb.2018.12.005
PubMed: 30557614
Affiliations:
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sort="Shi, Liang" uniqKey="Shi L" first="Liang" last="Shi">Liang Shi</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Yue, Si Ning" sort="Yue, Si Ning" uniqKey="Yue S" first="Si-Ning" last="Yue">Si-Ning Yue</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing 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Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yong Nan" sort="Liu, Yong Nan" uniqKey="Liu Y" first="Yong-Nan" last="Liu">Yong-Nan Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Ren, Ang" sort="Ren, Ang" uniqKey="Ren A" first="Ang" last="Ren">Ang Ren</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of 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Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Ming Wen" sort="Zhao, Ming Wen" uniqKey="Zhao M" first="Ming-Wen" last="Zhao">Ming-Wen Zhao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China. Electronic address: mwzhao@njau.edu.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu</wicri:regionArea><wicri:noRegion>Jiangsu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Fungal genetics and biology : FG & B</title><idno type="eISSN">1096-0937</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Wall (genetics)</term><term>Cell Wall (metabolism)</term><term>Chitin (chemistry)</term><term>Chitin (genetics)</term><term>MAP Kinase Signaling System (genetics)</term><term>Mitogen-Activated Protein Kinases (chemistry)</term><term>Mitogen-Activated Protein Kinases (genetics)</term><term>Phosphorylation (MeSH)</term><term>RNA Interference (MeSH)</term><term>Reishi (genetics)</term><term>Reishi (metabolism)</term><term>Saccharomyces cerevisiae (genetics)</term><term>Saccharomyces cerevisiae (metabolism)</term><term>Saccharomyces cerevisiae Proteins (chemistry)</term><term>Saccharomyces cerevisiae Proteins (genetics)</term><term>Sirolimus (metabolism)</term><term>TOR Serine-Threonine Kinases (genetics)</term><term>TOR Serine-Threonine Kinases (metabolism)</term><term>beta-Glucans (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Chitine (composition chimique)</term><term>Chitine (génétique)</term><term>Interférence par ARN (MeSH)</term><term>Mitogen-Activated Protein Kinases (composition chimique)</term><term>Mitogen-Activated Protein Kinases (génétique)</term><term>Paroi cellulaire (génétique)</term><term>Paroi cellulaire (métabolisme)</term><term>Phosphorylation (MeSH)</term><term>Protéines de Saccharomyces cerevisiae (composition chimique)</term><term>Protéines de Saccharomyces cerevisiae (génétique)</term><term>Reishi (génétique)</term><term>Reishi (métabolisme)</term><term>Saccharomyces cerevisiae (génétique)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Sirolimus (métabolisme)</term><term>Système de signalisation des MAP kinases (génétique)</term><term>Sérine-thréonine kinases TOR (génétique)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>bêta-Glucanes (composition chimique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Chitin</term><term>Mitogen-Activated Protein Kinases</term><term>Saccharomyces cerevisiae Proteins</term><term>beta-Glucans</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Chitine</term><term>Mitogen-Activated Protein Kinases</term><term>Protéines de Saccharomyces cerevisiae</term><term>bêta-Glucanes</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Wall</term><term>Chitin</term><term>MAP Kinase Signaling System</term><term>Mitogen-Activated Protein Kinases</term><term>Reishi</term><term>Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae Proteins</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Chitine</term><term>Mitogen-Activated Protein Kinases</term><term>Paroi cellulaire</term><term>Protéines de Saccharomyces cerevisiae</term><term>Reishi</term><term>Saccharomyces cerevisiae</term><term>Système de signalisation des MAP kinases</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Wall</term><term>Reishi</term><term>Saccharomyces cerevisiae</term><term>Sirolimus</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Paroi cellulaire</term><term>Reishi</term><term>Saccharomyces cerevisiae</term><term>Sirolimus</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Phosphorylation</term><term>RNA Interference</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Interférence par ARN</term><term>Phosphorylation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The fungal cell wall is very important for cell growth and survival during stress, and the target of rapamycin (TOR) pathway plays a major role in regulating cell growth in response to environmental cues. Ganoderma lucidum is an important edible and medicinal fungus, and the function of TOR in this organism remains unclear. As shown in the present study, the TOR pathway regulates cell wall integrity (CWI) in G. lucidum. Inhibition of TOR signaling by RNA interference (RNAi) or rapamycin treatment reduced the growth of G. lucidum mycelia, increased contents of the cell wall components chitin and β-1,3-glucan, and increased cell wall thickness. Furthermore, inhibition of TOR signaling enhanced the relative level of phosphorylated Slt2, a member of the MAPK cascade involved in CWI signaling. Moreover, when treated with rapamycin, significantly lower chitin and β-1,3-glucan contents were observed in Slt2-silenced strains than in WT strains, indicating that TOR regulates the synthesis of these cell wall components through the Slt2-MAPK pathway. These results indicate a potential relationship between TOR signaling and CWI signaling. Additionally, participation of Slt2-MAPK in TOR-mediated regulation of cell wall component production has not previously been reported in a microorganism.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30557614</PMID><DateCompleted><Year>2019</Year><Month>06</Month><Day>24</Day></DateCompleted><DateRevised><Year>2019</Year><Month>06</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0937</ISSN><JournalIssue CitedMedium="Internet"><Volume>123</Volume><PubDate><Year>2019</Year><Month>02</Month></PubDate></JournalIssue><Title>Fungal genetics and biology : FG & B</Title><ISOAbbreviation>Fungal Genet Biol</ISOAbbreviation></Journal><ArticleTitle>The Slt2-MAPK pathway is involved in the mechanism by which target of rapamycin regulates cell wall components in Ganoderma lucidum.</ArticleTitle><Pagination><MedlinePgn>70-77</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1087-1845(18)30296-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.fgb.2018.12.005</ELocationID><Abstract><AbstractText>The fungal cell wall is very important for cell growth and survival during stress, and the target of rapamycin (TOR) pathway plays a major role in regulating cell growth in response to environmental cues. Ganoderma lucidum is an important edible and medicinal fungus, and the function of TOR in this organism remains unclear. As shown in the present study, the TOR pathway regulates cell wall integrity (CWI) in G. lucidum. Inhibition of TOR signaling by RNA interference (RNAi) or rapamycin treatment reduced the growth of G. lucidum mycelia, increased contents of the cell wall components chitin and β-1,3-glucan, and increased cell wall thickness. Furthermore, inhibition of TOR signaling enhanced the relative level of phosphorylated Slt2, a member of the MAPK cascade involved in CWI signaling. Moreover, when treated with rapamycin, significantly lower chitin and β-1,3-glucan contents were observed in Slt2-silenced strains than in WT strains, indicating that TOR regulates the synthesis of these cell wall components through the Slt2-MAPK pathway. These results indicate a potential relationship between TOR signaling and CWI signaling. Additionally, participation of Slt2-MAPK in TOR-mediated regulation of cell wall component production has not previously been reported in a microorganism.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Dong-Dong</ForeName><Initials>DD</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Liang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yue</LastName><ForeName>Si-Ning</ForeName><Initials>SN</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Tian-Jun</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Sheng-Li</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yong-Nan</ForeName><Initials>YN</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>Ang</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Han-Shou</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Ming-Wen</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, Jiangsu, PR China. Electronic address: mwzhao@njau.edu.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Fungal Genet Biol</MedlineTA><NlmUniqueID>9607601</NlmUniqueID><ISSNLinking>1087-1845</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D047071">beta-Glucans</NameOfSubstance></Chemical><Chemical><RegistryNumber>1398-61-4</RegistryNumber><NameOfSubstance UI="D002686">Chitin</NameOfSubstance></Chemical><Chemical><RegistryNumber>9051-97-2</RegistryNumber><NameOfSubstance UI="C033363">beta-1,3-glucan</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="D020928">Mitogen-Activated Protein Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.11.24</RegistryNumber><NameOfSubstance UI="C072724">SLT2 protein, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>W36ZG6FT64</RegistryNumber><NameOfSubstance UI="D020123">Sirolimus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002473" MajorTopicYN="N">Cell Wall</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002686" MajorTopicYN="N">Chitin</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020935" MajorTopicYN="N">MAP Kinase Signaling System</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020928" MajorTopicYN="N">Mitogen-Activated Protein Kinases</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D034622" MajorTopicYN="N">RNA Interference</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020940" MajorTopicYN="N">Reishi</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D047071" MajorTopicYN="N">beta-Glucans</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Cell wall integrity</Keyword><Keyword MajorTopicYN="Y">Ganoderma lucidum</Keyword><Keyword MajorTopicYN="Y">Slt2-MAPK</Keyword><Keyword MajorTopicYN="Y">TOR</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>01</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>12</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>12</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>6</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>12</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30557614</ArticleId><ArticleId IdType="pii">S1087-1845(18)30296-2</ArticleId><ArticleId IdType="doi">10.1016/j.fgb.2018.12.005</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Dong Dong" sort="Chen, Dong Dong" uniqKey="Chen D" first="Dong-Dong" last="Chen">Dong-Dong Chen</name></noRegion><name sortKey="Liu, Yong Nan" sort="Liu, Yong Nan" uniqKey="Liu Y" first="Yong-Nan" last="Liu">Yong-Nan Liu</name><name sortKey="Ren, Ang" sort="Ren, Ang" uniqKey="Ren A" first="Ang" last="Ren">Ang Ren</name><name sortKey="Shi, Liang" sort="Shi, Liang" uniqKey="Shi L" first="Liang" last="Shi">Liang Shi</name><name sortKey="Wang, Sheng Li" sort="Wang, Sheng Li" uniqKey="Wang S" first="Sheng-Li" last="Wang">Sheng-Li Wang</name><name sortKey="Yu, Han Shou" sort="Yu, Han Shou" uniqKey="Yu H" first="Han-Shou" last="Yu">Han-Shou Yu</name><name sortKey="Yue, Si Ning" sort="Yue, Si Ning" uniqKey="Yue S" first="Si-Ning" last="Yue">Si-Ning Yue</name><name sortKey="Zhang, Tian Jun" sort="Zhang, Tian Jun" uniqKey="Zhang T" first="Tian-Jun" last="Zhang">Tian-Jun Zhang</name><name sortKey="Zhao, Ming Wen" sort="Zhao, Ming Wen" uniqKey="Zhao M" first="Ming-Wen" last="Zhao">Ming-Wen Zhao</name><name sortKey="Zhu, Jing" sort="Zhu, Jing" uniqKey="Zhu J" first="Jing" last="Zhu">Jing Zhu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix 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